GRK2243 Symposium on Ubiquitin 2020

GRK2243 Symposium

Understanding Ubiquitylation:

From Molecular Mechanisms to Disease

4-6 May 2020 I Würzburg, Germany

The Meeting

The post-translational modification of proteins with ubiquitin ("ubiquitylation") has taken center stage in eukaryotic cell biology. Ubiquitylation mediates the degradation of regulatory and damaged proteins, protein aggregates and even entire organelles. Moreover, it controls a wide variety of non-proteolytic processes, e.g. during DNA damage repair, receptor signaling and endocytosis.

Given the multi-faceted cellular functions of protein ubiquitylation, it is not surprising that abnormalities of the ubiquitin system lead to many human diseases including cancer, neurodegenerative disorders and infectious diseases. Moreover, the ubiquitin system has emerged as a promising target for therapeutic intervention, and drugs interfering with ubiquitin-mediated proteolysis are successfully used for the treatment of certain cancers.

This Symposium aims to showcase the most recent, exciting progress towards understanding molecular mechanisms, cellular functions and pathogenic aberrations of the ubiquitin system as well as developing novel therapeutic strategies targeting it. The meeting will feature cutting-edge research presentations by international leaders in the field, additional short talks selected from submitted abstracts, and a large poster session along with poster teasers. There will be ample opportunity for scientific interactions between all participants to stimulate further progress in ubiquitin research.

GRK2243

The Symposium is organized by the Research Training Group GRK2243, a ubiquitin-themed graduate program, which has been funded by the German Research Foundation DFG since April 2017. The GRK2243 offers cutting-edge research projects and a structured, interdisciplinary training program for more than 30 PhD students and postdocs at the University of Würzburg.

For further information, please visit our webpage:

www.uni-wuerzburg.de/grk2243

Program

REGISTRATION DEADLINE

1 February 2020

ABSTRACT SUBMISSION

DEADLINE

15 March 2020

Short talks will be selected from abstracts.

Find us on Twitter:
@grk2243

#wUeBI2020

Apply now!

Application will be open in due time.

Speakers

For further information, please click on the speakers’ portraits.

MRC LMB, UK

MRC LMB, UK

University of Washington, USA

Yale University, USA

Goethe University Frankfurt, DE

Harvard University, USA

University of Cologne, DE

University of Washington, USA

University Medicine Greifswald, DE

University of Dundee, UK

UC Berkeley, USA

Heidelberg University, DE

University of Duisburg-Essen, DE

VIB-KU Leuven, B

Netherlands Cancer Institute, NL

The Francis Crick Institute, UK

Friedrich Miescher Institute, CH

IMB Mainz, DE

University of Liverpool, UK

John Hopkins University, USA

Program

Day 1 - 4 May 2020

1.00 - 2.00 pm Arrival and registration

2.00 pm Welcome address

2.10 - 4.00 pm Session 1: Ubiquitin technology and tools

Keynote: Craig Crews - PROTAC-mediated protein degradation: the past, present and future

Huib Ovaa - Ubiquitin system chemistry

Helle Ulrich - Ubiquiton - a linkage-selective in vivo ubiquitylation tool

4.00 - 4.30 pm Coffee break

4.30 - 6.30 pm Session 2: DUBs

Sylvie Urbé - DUBs: Druggable regulators of protein and organelle homeostasis

Titia Sixma - Allosteric regulation of DUB enzymes

EMBO YIP talk: Yogesh Kulathu - Regulation of ubiquitin signalling by DUBs

Short talk 1 - tba

Short talk 2 - tba

6.40 - 7.10 pm Poster power show (2 min teaser presentations)

7.20 pm Poster session

& Finger food dinner

Day 2 - 5 May 2020

9.00 - 10.50 am Session 3: Ubiquitin-DNA transactions

Keynote: Cynthia Wolberger - Mechanism of cross-talk between histone
ubiquitination and methylation

Nicolas Thomä - Reprogramming CUL4 ligases with small molecules

Rachel Klevit - BRCA1/BARD1, twenty years later

10.50 - 11.20 am Coffee break

11.20 - 12.50 pm Session 3 ctd.: Ubiquitin-DNA transactions

Jesper Svejstrup - Ubiquitin in transcription, DNA repair and disease

Ivan Dikic - Unconventional serine ubiquitination

Short talk 1 - tba

Short talk 2 - tba

1.00 - 2.00 pm Lunch

2.00 - 4.15 pm Session 4: Cell cycle and signal transduction

David Barford - Regulation of APC/C activity by the spindle assembly checkpoint
during mitosis

Bruce Clurman - tba

Frauke Melchior - SUMOylation in signal transduction

Anna Sablina - Ubiquitin conjugation governs the interactomes of the RAS GTPases

Short talk 1 - tba

4.15 - 5.00 pm Coffee break

5.00 - 7.00 pm Leisure time to enjoy Würzburg

7.00 pm Conference dinner at Bürgerspital

Day 3 - 6 May 2020

9.00 - 10.50 am Session 5: Proteostasis

Keynote: Wade Harper - Understanding selective autophagy

Anne Bertolotti - Prolonging self-defense mechanism against misfolded protein as
a possible treatment against neurodegenerative diseases

Thorsten Hoppe - Impact of food perception on UPS, proteostasis, and aging

10.50 - 11.20 am Coffee break

11.20 - 1.05 pm Session 5 ctd.: Proteostasis

Hemmo Meyer - VCP/p97-mediated protein unfolding in cellular homeostasis and
signaling

Andreas Martin - Ubiquitin-dependent substrate processing by the 26S
proteasome

Elke Krüger - Cellular responses to proteasome impairment

Short talk 1 - tba

1.05 pm Closing remarks

Lunch (packed)

1.15 pm Departure

Complete Program as PDF

Registration & Fees

REGISTRATION DEADLINE

1 February 2020

ABSTRACT SUBMISSON DEADLINE

15 March 2020

Registration fees

PhD student, Postdoc 100 €

Academic 150 €

Industry 250 €

Online Application

Application will be open in due time.

Registration includes:

Conference materials
Access to all sessions
Conference dinner at Bürgerspital
Food and drinks during coffee breaks, lunches and finger food during poster session

Accommodation is not included. Please see hotel registration information under LOCATION below.

Payment

Please note that payment must be submitted only after receipt of confirmation that your registration has been accepted. At that point, you will receive an email from the organizers with detailed payment instructions. Payment ought to be made via national and international bank transfer exclusively. Credit card payment is not possible.

Cancellation and registration fee refund policy:

Notification of cancellation should be made in writing and sent to the conference organizers:
ubiquitin2020-grk2243@uni-wuerzburg.de
100% refund (less 25 € handling fee) if a notification e-mail reaches the organizers on or before
15 March 2020.
No refund on cancellations after 15 March 2020.

Selection criteria

The admission of participants (in case of overbooking) will be guided by the submitted abstracts, according to the expected scientific impact of the work on the conference and the field. It is thus recommended that all participants submit an abstract at the time of registration and specify whether they wish to present a poster or short talk.

For participants who do not plan to present their work, a CV (for principal investigators) or motivation letter (for students/post-docs) is requested.

Abstract guidelines

Please download the abstract template and follow the instructions therein.

Abstract template

Poster specifications

Please bring one printed copy of your poster in portrait orientation (not landscape).

POSTERS SHOULD HAVE A SIZE OF DIN A0 (84,1 x 118,9 cm).

Short talks

A number of short talks (10 min talk followed by 5 min discussion) – preferentially by early-career scientists – will be selected from the submitted abstracts ahead of the meeting.

Please indicate whether you would like to be considered for a short talk at the time of registration. Applicants will be notified at least three weeks before the meeting.

Contact

Coordinator GRK2243: Julia Seubert

Email: ubiquitin2020-grk2243@uni-wuerzburg.de